ITP is typically chronic (long-standing) in adults and acute in children. Idiopathic thrombocytopenic purpura (ITP) is immunologic thrombocytopenia in which the immune system mistakenly attacks the circulating platelets (autoimmune).
Increased platelet destruction can cause thrombocytopenia by immunologic and non-immunologic mechanisms. What Is Increased Platelet Destruction? Is It Cancer? alcohol toxicity from long-term alcohol abuse.Other causes of thrombocytopenia due to impaired bone marrow production of platelets include Many chemotherapeutic drugs commonly cause bone marrow toxicity and thrombocytopenia.
congenital disorders (Fanconi's anemia).some medications [chloramphenicol, gold, phenytoin ( Dilantin), valproic acid ( Depakene, Depakote, Depakote ER, Depacon).Some viral infections can cause low platelet count by affecting the bone marrow, for example,Īplastic anemia (agranulocytosis) is the terminology for bone marrow failure leading to low platelet count usually associated with anemia (low red cell count) and leukopenia or leucopenia (low white cell count). Usually, other blood cells (red and white) are also affected by some of these processes, and their numbers may be abnormal. Low platelet count due to impaired production is generally due to problems with the bone marrow. If surgery is planned in a patient with a platelet count less than 50,000, then transfusion may be necessary Most patients with thrombocytopenia do not require regular platelet transfusion. Treatment of thrombocytopenia, when necessary, consists of platelet transfusions.Signs of thrombocytopenia can include small pinpoint hemorrhages (petechiae) or bruises known as purpura.It often is identified when blood tests are ordered for other reasons or during routine screening. A blood test is used to diagnose thrombocytopenia.Viral infections may cause thrombocytopenia due to their effect on bone marrow, leading to decreased production of platelets.Other prescription drugs also may cause thrombocytopenia in certain cases.Heparin-induced thrombocytopenia (HIT) arises due to immune-mediated destruction of platelets that may occur with the blood thinner heparin and its related drugs.It also can occur when the spleen enlarges and sequesters more platelets than usual. Thrombocytopenia occurs because there is decreased production or increased destruction of platelets.With severe thrombocytopenia, excessive bleeding may occur.Platelets are important for normal blood clotting.Thrombocytopenia refers to an abnormally low level of platelets in the bloodstream.If you think you may have a medical emergency, call your physician or 911 immediately.Symptoms of a low platelet count can be bleeding gums and nosebleeds. By using this Site you agree to the following Terms and Conditions. We offer this Site AS IS and without any warranties. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site.
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